A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional psoriasis skin

T Cells

Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses

Nat Immunol. 2018

Park SL, Zaid A, Hor JL, Christo SN, Prier JE, Davies B, Alexandre YO, Gregory JL, Russell TA, Gebhardt T, Carbone FR, Tscharke DC, Heath WR, Mueller SN, Mackay LK

doi: 10.1038/s41590-017-0027-5.

Dynamical system modeling to simulate donor T cell response to whole exome sequencing-derived recipient peptides: Understanding randomness in alloreactivity incidence following stem cell transplantation

PLoS One.

Koparde V, Abdul Razzaq B, Suntum T, Sabo R, Scalora A, Serrano M, Jameson-Lee M, Hall C, Kobulnicky D, Sheth N, Feltz J, Contaifer D Jr, Wijesinghe D, Reed J, Roberts C, Qayyum R, Buck G, Neale M, Toor A

doi: 10.1371/

Vitiligo

Vitiligo skin T cells are prone to produce type 1- and type 2-cytokines to induce melanocyte dysfunction and epidermal inflammatory response through JAK signaling

J Invest Dermatol

Martins C, Migayron L, Drullion C, Jacquemin C, Lucchese F, Rambert J, Merhi R, Michon P, Taieb A, Rezvani HR, de Rinaldis E, Seneschal J, Boniface K

doi: 10.1016/j.jid.2021.09.015

Mycobacterium tuberculosis GrpE, A Heat-Shock Stress Responsive Chaperone, Promotes Th1-Biased T Cell Immune Response via TLR4-Mediated Activation of Dendritic Cells

Front Cell Infect Microbiol.

Kim WS, Jung ID, Kim JS, Kim HM, Kwon KW, Park YM, Shin SJ

doi: 10.3389/fcimb.2018.00095.

Psoriasis

Differential Changes in Inflammatory Mononuclear Phagocyte and T Cell Profiles within Psoriatic Skin during Treatment with Guselkumab versus Secukinumab

J Invest Dermatol

Mehta H, Mashiko S, Angsana J, Rubio M, Hsieh YM, Maari C, Reich K, Blauvelt A, Bissonnette R, Muñoz-Elías EJ, Sarfati M

doi: 10.1016/j.jid.2021.01.005

T Cells

The helminth-derived peptide GK-1 induces an anti-tumoral CD8 T cell response associated with downregulation of the PD-1/PD-L1 pathway

Clin Immunol.

Rodríguez-Rodríguez N, Madera-Salcedo IK, Bugarin-Estrada E, Sánchez-Miranda E, Torres-García D, Cervantes-Torres J, Fragoso G, Rosetti F, Crispín JC, Sciutto E

doi: 10.1016/j.clim.

Selective T-cell depletion targeting CD45RA reduces viremia and enhances early T-cell recovery compared to CD3-targeted T-cell depletion

Transpl Infect Dis.

Triplett BM, Muller B, Kang G, Ying L, Cross SJ, Moen J, Cunningham L, Janssen W, Mamcarz E, Shook DR, Srinivasan A, Choi J, Hayden RT, Leung W

doi: 10.1111/tid.12823.

Psoriasis

Association of the Psoriatic Microenvironment With Treatment Response

JAMA Dermatol.

Wang G, Miao Y, Kim N, Sweren E, Kang S, Hu Z, Garza LA

doi: 10.1001/jamadermatol.

Immunotherapy

Epigenetic mechanisms regulating T-cell responses

J Allergy Clin Immunol.

Schmidl C, Delacher M, Huehn J, Feuerer M

doi: 10.1016/j.jaci.2018.07.014.

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