Differential Changes in Inflammatory Mononuclear Phagocyte and T Cell Profiles within Psoriatic Skin during Treatment with Guselkumab versus Secukinumab

Atopic Dermatitis

Treatment for moderate to severe atopic dermatitis in alpine and moderate maritime climates differentially affects helper T cells and memory B cells in children

Clin Exp Allergy.

Heeringa JJ, Fieten KB, Bruins FM, van Hoffen E, Knol EF, Pasmans SGMA, van Zelm MC

doi: 10.1111/cea.13136.

Psoriatic Arthritis

Secukinumab versus adalimumab for treatment of active psoriatic arthritis (EXCEED): a double-blind, parallel-group, randomised, active-controlled, phase 3b trial

Lancet.

McInnes IB, Behrens F, Mease PJ, Kavanaugh A, Ritchlin C, Nash P, Masmitja JG, Goupille P, Korotaeva T, Gottlieb AB, Martin R, Ding K, Pellet P, Mpofu S, Pricop L, EXCEED Study Group

doi: 10.

ImmunotherapyT Cells

Cytometric analysis of T cell phenotype using cytokine profiling for improved manufacturing of an EBV-specific T cell therapy

Clin Exp Immunol

Cooper RS, Kowalczuk A, Wilkie G, Vickers MA, Turner ML, Campbell JDM, Fraser AR

doi: 10.1111/cei.13640

Systemic Lupus Erythematosus

IgM anti-phosphorylcholine antibodies associate with senescent and IL-17+ T cells in SLE patients with a pro-inflammatory lipid profile

Rheumatology (Oxford).

López P, Rodríguez-Carrio J, Martínez-Zapico A, Pérez-Álvarez ÁI, Benavente L, Caminal-Montero L, Suárez A

doi: 10.1093/rheumatology/

Vitiligo

Vitiligo skin T cells are prone to produce type 1- and type 2-cytokines to induce melanocyte dysfunction and epidermal inflammatory response through JAK signaling

J Invest Dermatol

Martins C, Migayron L, Drullion C, Jacquemin C, Lucchese F, Rambert J, Merhi R, Michon P, Taieb A, Rezvani HR, de Rinaldis E, Seneschal J, Boniface K

doi: 10.1016/j.jid.2021.09.015

Psoriasis

Eosin treatment for psoriasis reduces skin leukocyte infiltration and secretion of inflammatory chemokines and angiogenic factors

Eur J Dermatol.

Capriotti L, Didona B, Madonna S, Scarponi C, Pilla MA, Facchiano F, Cordella M, Cavani A, Failla CM

doi: 10.1684/ejd.2018.3357.

PsoriasisPsoriatic ArthritisSpinal Disorders

Incidence rates of inflammatory bowel disease in patients with psoriasis, psoriatic arthritis and ankylosing spondylitis treated with secukinumab: a retrospective analysis of pooled data from 21 clinical trials

Ann Rheum Dis.

Schreiber S, Colombel JF, Feagan BG, Reich K, Deodhar AA, McInnes IB, Porter B, Das Gupta A, Pricop L, Fox T

doi: 10.1136/annrheumdis-2018-214273.

T Cells

The Metabolic Profile of Tumor and Virally Infected Cells Shapes Their Microenvironment Counteracting T Cell Immunity

Front Immunol.

Magalhaes I, Yogev O, Mattsson J, Schurich A

doi: 10.3389/fimmu.2019.02309.