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ImmunodeficiencyT Cells

Neutrophil and Granulocytic Myeloid-Derived Suppressor Cell-Mediated T Cell Suppression Significantly Contributes to Immune Dysregulation in Common Variable Immunodeficiency Disorders

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Vlkova M, Chovancova Z, Nechvatalova J, Connelly AN, Davis MD, Slanina P, Travnickova L, Litzman M, Grymova T, Soucek P, Freiberger T, Litzman J, Hel Z

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T Cells

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T Cells

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doi: 10.1016/j.clim.

T Cells

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T Cells

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Front Immunol.

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doi: 10.3389/fimmu.2019.02309.

Autoimmune Disease

Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-γ secreting cells

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Liaskou E, Patel SR, Webb G, Bagkou Dimakou D, Akiror S, Krishna M, Mells G, Jones DE, Bowman SJ, Barone F, Fisher BA, Hirschfield GM

doi: 10.1016/j.jaut.2018.07.020.

ImmunotherapyT Cells

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Front Immunol.

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Immunotherapy

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