The effect of tranexamic acid by baseline risk in acute bleeding patients: a meta-analysis of individual patient-level data from 28 333 patients

General Anesthesia

Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data

Lancet Neurol.

Campbell BCV, van Zwam WH, Goyal M, Menon BK, Dippel DWJ, Demchuk AM, Bracard S, White P, Dávalos A, Majoie CBLM, van der Lugt A, Ford GA, de la Ossa NP, Kelly M, Bourcier R, Donnan GA, Roos YBWEM, Bang OY, Nogueira RG, Devlin TG, van den Berg LA, Clarençon F, Burns P, Carpenter J, Berkhemer OA, Yavagal DR, Pereira VM, Ducrocq X, Dixit A, Quesada H, Epstein J, Davis SM, Jansen O, Rubiera M, Urra X, Micard E, Lingsma HF, Naggara O, Brown S, Guillemin F, Muir KW, van Oostenbrugge RJ, Saver JL, Jovin TG, Hill MD, Mitchell PJ; HERMES collaborators.

doi: 10.1016/

RECOMMENDED

Mechanical Ventilation

Effects of early extubation followed by noninvasive ventilation versus standard extubation on the duration of invasive mechanical ventilation in hypoxemic non-hypercapnic patients: a systematic review and individual patient data meta-analysis of randomized controlled trials

★ 3 Recommended by Dr Martin Frey, Faculty Member

★ 2 Recommended by Dr Marcus Hesse, Faculty Member

Crit Care

Vaschetto R, Pecere A, Perkins GD, Mistry D, Cammarota G, Longhini F, Ferrer M, Pletsch-Assunção R, Carron M, Moretto F, Qiu H, Della Corte F, Barone-Adesi F, Navalesi P

doi: 10.1186/s13054-021-03595-5

Pain Management

Placebo Effects on the Neurologic Pain Signature: A Meta-analysis of Individual Participant Functional Magnetic Resonance Imaging Data

JAMA Neurol.

Zunhammer M, Bingel U, Wager TD, Placebo Imaging Consortium

doi: 10.1001/

Bacterial Infections

Procalcitonin-guided antibiotic treatment in patients with positive blood cultures: A patient-level meta-analysis of randomized trials

Clin Infect Dis.

Meier MA, Branche A, Neeser OL, Wirz Y, Haubitz S, Bouadma L, Wolff M, Luyt CE, Chastre J, Tubach F, Christ-Crain M, Corti C, Jensen JS, Deliberato RO, Kristoffersen KB, Damas P, Nobre V, Oliveira CF, Shehabi Y, Stolz D, Tamm M, Mueller B, Schuetz P

doi: 10.1093/cid/ciy917.

Bacterial Infections

Chest X-ray analysis with deep learning-based software as a triage test for pulmonary tuberculosis: an individual patient data meta-analysis of diagnostic accuracy

Clin Infect Dis

Tavaziva G, Harris M, Abidi SK, Geric C, Breuninger M, Dheda K, Esmail A, Muyoyeta M, Reither K, Majidulla A, Khan AJ, Campbell JR, David PM, Denkinger C, Miller C, Nathavitharana R, Pai M, Benedetti A, Khan FA

doi: 10.1093/cid/ciab639

Respiratory Tract InfectionViral Infections, Non-HIV

Efficacy and Safety of Oseltamivir in Children: Systematic Review and Individual Patient Data Meta-analysis of Randomized Controlled Trials

Clin Infect Dis.

Malosh RE, Martin ET, Heikkinen T, Brooks WA, Whitley RJ, Monto AS

doi: 10.1093/cid/cix1040.

Acute Pain

Side Effect Rates of Opioids in Equianalgesic Doses Via Intravenous Patient-Controlled Analgesia: A Systematic Review and Network Meta-analysis

Anesth Analg.

Dinges HC, Otto S, Stay DK, Bäumlein S, Waldmann S, Kranke P, Wulf HF, Eberhart LH

doi: 10.1213/ANE.

General Anesthesia

Association of General Anesthesia vs Procedural Sedation With Functional Outcome Among Patients With Acute Ischemic Stroke Undergoing Thrombectomy: A Systematic Review and Meta-analysis

JAMA.

Schönenberger S, Hendén PL, Simonsen CZ, Uhlmann L, Klose C, Pfaff JAR, Yoo AJ, Sørensen LH, Ringleb PA, Wick W, Kieser M, Möhlenbruch MA, Rasmussen M, Rentzos A, Bösel J

doi: 10.1001/jama.2019.11455.

Viral Infections, Non-HIV

Risk factors for the exacerbation of patients with 2019 Novel Coronavirus: A meta-analysis

Int J Med Sci.

Zhao J, Li X, Gao Y, Huang W

doi: 10.7150/ijms.47052.

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