Efficacy and Safety of Single and Multiple Doses of a Fixed-dose Combination of Ibuprofen and Acetaminophen in the Treatment of Postsurgical Dental Pain: Results from Two Phase 3, Randomized, Parallel-Group, Double-Blind, Placebo-Controlled Studies

Postoperative Pain

Efficacy and safety of single-dose DFN-15 for treatment of acute postsurgical dental pain: a randomized, double-blind, placebo-controlled study

Pain

Singla N, Bertoch T, Shenoy S, Munjal S

doi: 10.1097/j.pain.0000000000002312

Acute PainBack Pain

A randomized, placebo- and active-controlled, multi-country, multi-center parallel group trial to evaluate the efficacy and safety of a fixed-dose combination of 400 mg ibuprofen and 100 mg caffeine compared with ibuprofen 400 mg and placebo in patients with acute lower back or neck pain

J Pain Res.

Predel HG, Ebel-Bitoun C, Lange R, Weiser T

doi: 10.2147/JPR.S217045.

Acute Pain

Efficacy and safety of multiple doses of tapentadol oral solution in the treatment of moderate to severe acute pain in children aged 2 to <18 years - a randomized, double-blind, placebo-controlled trial

J Pain Res.

Beuter C, Volkers G, Radic T, Goldberg J, van den Anker J

doi: 10.2147/JPR.S207010.

Back Pain

Tanezumab for chronic low back pain: a randomized, double-blind, placebo- and active-controlled, phase 3 study of efficacy and safety

Pain.

Markman JD, Bolash RB, McAlindon TE, Kivitz AJ, Pombo-Suarez M, Ohtori S, Roemer FW, Li DJ, Viktrup L, Bramson C, West CR, Verburg KM

doi: 10.1097/j.pain.0000000000001928.

Complex Regional Pain Syndrome (CRPS)Neuropathic PainPain Relief

Efficacy and Safety of Lidocaine Infusion Treatment for Neuropathic Pain: A Randomized, Double-Blind, and Placebo-Controlled Study

Reg Anesth Pain Med.

Kim YC, Castañeda AM, Lee CS, Jin HS, Park KS, Moon JY

doi: 10.1097/

Respiratory Tract Infection

Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from a randomised, double-blind, placebo-controlled, phase 3 trial

Lancet

Reich K, Teixeira HD, de Bruin-Weller M, Bieber T, Soong W, Kabashima K, Werfel T, Zeng J, Huang X, Hu X, Hendrickson BA, Ladizinski B, Chu AD, Silverberg JI

doi: 10.1016/S0140-6736(21)00589-4

Chronic Pain

Long-term use of naldemedine in the treatment of opioid-induced constipation in patients with chronic non-cancer pain: a randomized, double-blind, placebo-controlled phase 3 study

Pain.

Webster LR, Nalamachu S, Morlion B, Reddy J, Baba Y, Yamada T, Arjona Ferreira JC

doi: 10.1097/

COMMENTED

Chronic Pain

The Pharmacokinetics, Efficacy, and Safety of a Novel Selective-Dose Cannabis Inhaler in Patients with Chronic Pain: A Randomized, Double-Blinded, Placebo-Controlled Trial

★ 3 Recommended and commented by Dr Roland Schreiber, Faculty Member

Eur J Pain.

Almog S, Aharon-Peretz J, Vulfsons S, Ogintz M, Abalia H, Lupo T, Hayon Y, Eisenberg E

doi: 10.1002/ejp.1605.

Viral Infections, Non-HIV

Efficacy and safety of an inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac): interim results of a double-blind, randomised, placebo-controlled, phase 3 trial in Turkey