IFN&#x3B3;-producing CD8⁺ tissue resident memory T cells are a targetable hallmark of immune checkpoint inhibitor-colitis

COMMENTED

Inflammatory Bowel Disease

Outcomes of vedolizumab therapy in patients with immune checkpoint inhibitor-induced colitis: a multi-center study

doi: 10.1186/s40425-018-0461-4.

Inflammatory Bowel Disease

Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease

Gastroenterology.

Mitsialis V, Wall S, Liu P, Ordovas-Montanes J, Parmet T, Vukovic M, Spencer D, Field M, McCourt C, Toothaker J, Bousvaros A, BCH IBD Center., BWH Crohn’s and Colitis Center., Shalek AK, Kean L, Horwitz B, Goldsmith J, Tseng G, Snapper SB, Konnikova L

doi: 10.1053/j.gastro.2020.04.074.

Further Publications

24-NorUrsodeoxycholic acid reshapes immunometabolism in CD8⁺ T-cells and alleviates hepatic inflammation

J Hepatol

Zhu C, Boucheron N, Müller AC, Májek P, Claudel T, Halilbasic E, Baazim H, Lercher A, Viczenczova C, Hainberger D, Preglej T, Sandner L, Alteneder M, Gülich AF, Khan M, Hamminger P, Remetic J, Ohradanova-Repic A, Schatzlmaier P, Donner C, Fuchs CD, Stojakovic T, Scharnagl H, Sakaguchi S, Weichhart T, Bergthaler A, Stockinger H, Ellmeier W, Trauner M

doi: 10.1016/j.jhep.2021.06.036

Pancreas Diseases

Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

Gut.

Knudsen ES, Kumarasamy V, Chung S, Ruiz A, Vail P, Tzetzo S, Wu J, Nambiar R, Seshadri M, Abrams SI, Wang J, Witkiewicz AK

doi: 10.1136/gutjnl-2020-321000.

Hepatology

Impaired antibacterial response of liver sinusoidal Vγ9⁺Vδ2⁺ T cells in patients with chronic liver disease

Gut

Rha MS, Han JW, Koh JY, Lee HS, Kim JH, Cho K, Kim SI, Kim MS, Lee JG, Park SH, Joo DJ, Park JY, Shin EC

doi: 10.1136/gutjnl-2020-322182

Hepatitis

Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

J Hepatol.

Renand A, Cervera-Marzal I, Gil L, Dong C, Garcia A, Kervagoret E, Auble H, Habes S, Chevalier C, Vavasseur F, Clémenceau B, Cardon A, Judor JP, Mosnier JF, Tanné F, Laplaud DA, Brouard S, Gournay J, Milpied P, Conchon S

doi: 10.1016/j.jhep.2020.05.053.

Gastrointestinal Cancer

Hepatotoxicity from Immune Checkpoint Inhibitors: A Systematic Review and Management Recommendation

Hepatology.

Peeraphatdit TB, Wang J, Odenwald MA, Hu S, Hart J, Charlton MR

doi: 10.1002/hep.31227.

Gastrointestinal Cancer

Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma

J Hepatol.

Sangro B, Chan SL, Meyer T, Reig M, El-Khoueiry A, Galle PR

doi: 10.1016/j.jhep.2019.10.021.

Inflammatory Bowel Disease

A Crohn's disease-associated IL2RA enhancer variant determines the balance of T cell immunity by regulating responsiveness to IL-2 signaling

J Crohns Colitis

Goldberg R, Clough JN, Roberts LB, Sanchez J, Kordasti S, Petrov N, Hertweck A, Lorenc A, Jackson I, Tasker S, Appios A, Omer O, Parkes M, Prescott N, Jenner RG, Irving PM, Lord GM

doi: 10.1093/ecco-jcc/jjab103

Related content

Outcomes of vedolizumab therapy in patients with immune checkpoint inhibitor-induced colitis: a multi-center study

Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease

24-NorUrsodeoxycholic acid reshapes immunometabolism in CD8+ T-cells and alleviates hepatic inflammation

Targeting dual signalling pathways in concert with immune checkpoints for the treatment of pancreatic cancer

Impaired antibacterial response of liver sinusoidal Vγ9+Vδ2+ T cells in patients with chronic liver disease

Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

Hepatotoxicity from Immune Checkpoint Inhibitors: A Systematic Review and Management Recommendation

Diagnosis and management of toxicities of immune checkpoint inhibitors in hepatocellular carcinoma

A Crohn's disease-associated IL2RA enhancer variant determines the balance of T cell immunity by regulating responsiveness to IL-2 signaling

24-NorUrsodeoxycholic acid reshapes immunometabolism in CD8⁺ T-cells and alleviates hepatic inflammation

Impaired antibacterial response of liver sinusoidal Vγ9⁺Vδ2⁺ T cells in patients with chronic liver disease