Efficacy of Rosuvastatin in Children With Homozygous Familial Hypercholesterolemia and Association With Underlying Genetic Mutations

Heart, Artery and Coronary DiseasesLipid-Lowering Drugs

Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children with Heterozygous Familial Hypercholesterolemia: The CHARON Study

Circulation.

Braamskamp MJAM, Langslet G, McCrindle BW, Cassiman DM, Francis GA, Gagne C, Gaudet D, Morrison KM, Wiegman A, Turner T, Miller E, Kusters DM, Raichlen JS, Martin PD, Stein EA, Kastelein JJP, Hutten BA

doi: 10.1161/CIRCULATIONAHA.

Cardiovascular Risk and DiseasesHeart, Artery and Coronary DiseasesLipid-Lowering Drugs

Statins for children with familial hypercholesterolemia

Cochrane Database Syst Rev.

Vuorio A, Kuoppala J, Kovanen PT, Humphries SE, Tonstad S, Wiegman A, Drogari E, Ramaswami U

doi: 10.1002/14651858.

RECOMMENDED

Heart, Artery and Coronary DiseasesLipid-Lowering Drugs

Evinacumab for Homozygous Familial Hypercholesterolemia

★ 3 Recommended by Prof. Dr Isabella Sudano, Faculty Member

N Engl J Med.

Raal FJ, Rosenson RS, Reeskamp LF, Hovingh GK, Kastelein JJP, Rubba P, Ali S, Banerjee P, Chan KC, Gipe DA, Khilla N, Pordy R, Weinreich DM, Yancopoulos GD, Zhang Y, Gaudet D, ELIPSE HoFH Investigators

doi: 10.1056/NEJMoa2004215.

Further Publications

Genetic testing is essential for initiating statin therapy in children with familial hypercholesterolemia: Examples from Scandinavia

Atherosclerosis

Svendsen K, Langslet G, Krogh HW, Brinck J, Klausen IC, Stenehjem JS, Holven KB, Bogsrud MP, Retterstøl K

doi: 10.1016/j.atherosclerosis.2020.11.027

Cardiac Arrest or Death

Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death

J Am Heart Assoc.

Mitchell RN, Ashar FN, Jarvelin MR, Froguel P, Sotoodehnia N, Brody JA, Sebert S, Huikuri H, Rioux J, Goyette P, Newcomb CE, Junttila MJ, Arking DE

doi: 10.1161/JAHA.119.013751.

RECOMMENDED

Heart, Artery and Coronary DiseasesLipid-Lowering Drugs

Long term follow-up of genetically confirmed patients with familial hypercholesterolemia treated with first and second-generation statins and then with PCSK9 monoclonal antibodies

★ 2 Recommended by Prof. Dr Isabella Sudano, Faculty Member

Atherosclerosis.

Pasta A, Cremonini AL, Formisano E, Fresa R, Bertolini S, Pisciotta L

doi: 10.1016/j.atherosclerosis.2020.07.006.

Cardiovascular Risk and DiseasesLipid-Lowering Drugs

Long-term treatment with evolocumab added to conventional drug therapy, with or without apheresis, in patients with homozygous familial hypercholesterolaemia: an interim subset analysis of the open-label TAUSSIG study

Lancet Diabetes Endocrinol.

Raal FJ, Hovingh GK, Blom D, Santos RD, Harada-Shiba M, Bruckert E, Couture P, Soran H, Watts GF, Kurtz C, Honarpour N, Tang L, Kasichayanula S, Wasserman SM, Stein EA

doi: 10.1016/S2213-8587

COMMENTED

Heart, Artery and Coronary Diseases

Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia: A Global Call to Action

★ 3 Recommended and commented by Prof. Dr Isabella Sudano, Faculty Member

doi: 10.1001/jamacardio.2019.5173.

Heart, Artery and Coronary DiseasesLipid-Lowering Drugs

Impact of clinical signs and genetic diagnosis of familial hypercholesterolaemia on the prevalence of coronary artery disease in patients with severe hypercholesterolaemia

Eur Heart J.

Tada H,Kawashiri M, Nohara A, Inazu A, Mabuchi H, Yamagishi M

doi: 10.1093/eurheartj/ehx004.

Related content

Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children with Heterozygous Familial Hypercholesterolemia: The CHARON Study

Statins for children with familial hypercholesterolemia

Evinacumab for Homozygous Familial Hypercholesterolemia

Genetic testing is essential for initiating statin therapy in children with familial hypercholesterolemia: Examples from Scandinavia

Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death

Long term follow-up of genetically confirmed patients with familial hypercholesterolemia treated with first and second-generation statins and then with PCSK9 monoclonal antibodies

Long-term treatment with evolocumab added to conventional drug therapy, with or without apheresis, in patients with homozygous familial hypercholesterolaemia: an interim subset analysis of the open-label TAUSSIG study

Reducing the Clinical and Public Health Burden of Familial Hypercholesterolemia: A Global Call to Action

Impact of clinical signs and genetic diagnosis of familial hypercholesterolaemia on the prevalence of coronary artery disease in patients with severe hypercholesterolaemia