Prospective Randomized Double-Blind, Placebo Controlled Evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia (PRESERVE-1)

Overactive Bladder

International Phase III, Randomized, Double-Blind, Placebo- and Active-Controlled Study to Evaluate the Safety and Efficacy of Vibegron in Patients with Symptoms of Overactive Bladder: EMPOWUR

J Urol.

Staskin D, Frankel J, Varano S, Shortino D, Jankowich R, Mudd PN Jr

doi: 10.1097/JU.0000000000000807.

Erectile and Sexual Functions and Dysfunctions

A Double Blind, Placebo Controlled, Randomized Trial to Evaluate the Efficacy and Tolerability of On-Demand Oral Pregablin (150 mg and 75 mg) in Treatment of Premature Ejaculation

J Sex Med.

El Najjar MR, El Hariri M, Ramadan A, Hefny Hashem AA

doi: 10.1016/j.jsxm.2019.12.014.

A randomized, multicenter, double-blind study to evaluate the safety and efficacy of estradiol vaginal cream 0.003% in postmenopausal women with dyspareunia as the most bothersome symptom

Menopause.

Kroll R, Archer DF, Lin Y, Sniukiene V, Liu JH

doi: 10.1097/GME.

Lower Urinary Tract Symptoms

Efficacy and Safety of Desmopressin Add-On Therapy for Men with Persistent Nocturia on α-Blocker Monotherapy for Lower Urinary Tract Symptoms: A Randomized, Double-Blind, Placebo Controlled Study.

J Urol.

Kim JC, Cho KJ, Lee JG, Seo JT, Kim DY, Oh SJ, Lee KS, Choo MS, Lee JZ

doi: 10.1016/j.juro.2016.08.116.

Lower Urinary Tract Symptoms

Tamsulosin and placebo versus tamsulosin and tadalafil in male lower urinary tract symptoms: A double-blinded, randomized controlled trial

BJU Int.

Nagasubramanian S, John NT, Antonisamy B, Mukha RP, Chandrasingh J, Kumar S, Devasia A, Kekre NS

doi: 10.1111/bju.15027.

Overactive Bladder

Efficacy, safety, and tolerability of mirabegron in patients aged ≥65yr with overactive bladder wet: a phase IV, double-blind, randomised, placebo-controlled study (PILLAR)

Eur Urol.

Wagg A, Staskin D, Engel E, Herschorn S, Kristy RM, Schermer CR

doi: 10.1016/j.eururo.2019.10.002.

Pregnancy and Childbirth

Early vaginal progesterone versus Placebo in Twin Pregnancies for prevention of spontaneous preterm birth (EVENTS): A randomised double-blind trial

Am J Obstet Gynecol.

Rehal A, Benkő Z, De Paco Matallana C, Syngelaki A, Janga D, Cicero S, Akolekar R, Singh M, Chaveeva P, Burgos J, Molina FS, Savvidou M, De La Calle M, Persico N, Quezada Rojas MS, Sau A, Greco E, O'Gorman N, Plasencia W, Pereira S, Jani JC, Valino N, Gil MDM, Maclagan K, Wright A, Wright D, Nicolaides KH

doi: 10.1016/j.ajog.2020.06.050.

Intravenous Mannitol Versus Placebo During Partial Nephrectomy in Patients with Normal Kidney Function: A Double-blind, Clinically-integrated, Randomized Trial

Eur Urol.

Spaliviero M, Power NE, Murray KS, Sjoberg DD, Benfante NE, Bernstein ML, Wren J, Russo P, Coleman JA

doi: 10.1016/j.eururo.2017.07.038.

Pregnancy and Childbirth

Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia

N Engl J Med.

Rolnik DL, Wright D, Poon LC, O'Gorman N, Syngelaki A, de Paco Matallana C, Akolekar R, Cicero S, Janga D, Singh M, Molina FS, Persico N, Jani JC, Plasencia W, Papaioannou G, Tenenbaum-Gavish K, Meiri H, Gizurarson S, Maclagan K, Nicolaides KH

doi: 10.1056/NEJMoa1704559.

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