Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sj&#xF6;gren&apos;s syndrome

EULAR ^® 2020

Sjögren’s Syndrome

Autoimmune Disease

Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-γ secreting cells

J Autoimmun.

Liaskou E, Patel SR, Webb G, Bagkou Dimakou D, Akiror S, Krishna M, Mells G, Jones DE, Bowman SJ, Barone F, Fisher BA, Hirschfield GM

doi: 10.1016/j.jaut.2018.07.020.

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Interleukin 6 receptor inhibition in primary Sjögren syndrome: a multicentre double-blind randomised placebo-controlled trial

Ann Rheum Dis

Felten R, Devauchelle-Pensec V, Seror R, Duffau P, Saadoun D, Hachulla E, Pierre Yves H, Salliot C, Perdriger A, Morel J, Mékinian A, Vittecoq O, Berthelot JM, Dernis E, Le Guern V, Dieudé P, Larroche C, Richez C, Martin T, Zarnitsky C, Blaison G, Kieffer P, Maurier F, Dellal A, Rist S, Andres E, Contis A, Chatelus E, Sordet C, Sibilia J, Arnold C, Tawk MY, Aberkane O, Holterbach L, Cacoub P, Saraux A, Mariette X, Meyer N, Gottenberg JE

doi: 10.1136/annrheumdis-2020-218467

Further Publications DermatologyFurther Publications ImmunologyFurther Publications Rheumatology

Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome

Arthritis Res Ther.

Hargreaves P, Daoudlarian D, Theron M, Kolb FA, Manchester Young M, Reis B, Tiaden A, Bannert B, Kyburz D, Manigold T

doi: 10.1186/s13075-019-1955-2.

Systemic Lupus Erythematosus

Sjögren's syndrome in Systemic Lupus Erythematosus - a subset characterized by a systemic inflammatory state

J Rheumatol.

Ruacho G, Kvarnström M, Zickert A, Oke V, Rönnelid J, Eketjäll S, Elvin K, Gunnarsson I, Svenungsson E

doi: 10.3899/jrheum.190250.

Further Publications DermatologyFurther Publications ImmunologyFurther Publications Rheumatology

Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome

Rheumatology (Oxford).

Thorlacius GE, Hultin-Rosenberg L, Sandling JK, Bianchi M, Imgenberg-Kreuz J, Pucholt P, Theander E, Kvarnström M, Forsblad-d'Elia H, Bucher SM, Norheim KB, Johnsen SJA, Hammenfors D, Skarstein K, Jonsson MV, Baecklund E, Aqrawi LA, Jensen JL, Palm Ø, Morris AP, DISSECT consortium ., the ImmunoArray consortium ., Meadows JRS, Rantapää-Dahlqvist S, Mandl T, Eriksson P, Lind L, Omdal R, Jonsson R, Lindblad-Toh K, Rönnblom L, Wahren-Herlenius M, Nordmark G

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Autoimmune Disease

Efficacy and safety of abatacept in active primary Sjögren's syndrome: results of a phase III, randomised, placebo-controlled trial

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Baer AN, Gottenberg JE, St Clair EW, Sumida T, Takeuchi T, Seror R, Foulks G, Nys M, Mukherjee S, Wong R, Ray N, Bootsma H

doi: 10.1136/annrheumdis-2020-218599

Autoimmune Disease

Lymphopenia in primary Sjögren's syndrome is associated with premature aging of naïve CD4+ T cells

Rheumatology (Oxford).

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Two shared immune cell signatures stratify patients with Sjögren's syndrome and systemic lupus erythematosus with potential therapeutic implications

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doi: 10.1002/art.41708

Dermatology · Immunology · Rheumatology

Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjögren's syndrome

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Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-γ secreting cells

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