Interleukin-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation

Gout

NEUTROPHIL EXTRACELLULAR TRAPS RELEASE IN GOUT AND PSEUDOGOUT DEPENDS ON THE NUMBER OF CRYSTALS REGARDLESS OF LEUKOCYTE COUNT

Rheumatology (Oxford)

Garcia-Gonzalez E, Gamberucci A, Lucherini OM, Alì A, Simpatico A, Lorenzini S, Lazzerini PE, Tripodi S, Frediani B, Selvi E

doi: 10.1093/rheumatology/keab087

Further Publications DermatologyFurther Publications ImmunologyFurther Publications Rheumatology

Tamoxifen restores extracellular trap formation in neutrophils from patients of chronic granulomatous disease, in ROS-independent manner

J Allergy Clin Immunol.

Sharma A, McCann K, Tripathi JK, Chauhan P, Zerbe C, Mishra BB, Holland SM, Sharma J

doi: 10.1016/j.jaci.

Systemic Lupus Erythematosus

Neutrophil extracellular traps identify patients at risk of increased disease activity and cardiovascular comorbidity in systemic lupus erythematosus

J Rheumatol.

Moore S, Juo HH, Nielsen CT, Tyden H, Bengtsson AA, Lood C

doi: 10.3899/jrheum.190875.

Immunodeficiency

Modulation of the Interleukin-21 Pathway with Interleukin-4 Distinguishes Common Variable Immunodeficiency Patients with More Non-infectious Clinical Complications

J Clin Immunol.

Desjardins M, Béland M, Dembele M, Lejtenyi D, Drolet JP, Lemire M, Tsoukas C, Ben-Shoshan M, Noya FJD, Alizadehfar R, McCusker CT, Mazer BD

doi: 10.1007/s10875-017-0452-0.

Rheumatoid Arthritis

Janus kinase inhibitors prevent migration of rheumatoid arthritis neutrophils towards interleukin-8, but do not inhibit priming of the respiratory burst or reactive oxygen species production

Clin Exp Immunol.

Mitchell TS, Moots RJ, Wright HL

doi: 10.1111/cei.12970.

Rheumatoid Arthritis

Effect of tocilizumab on neutrophils in adult patients with rheumatoid arthritis: pooled analysis of data from phase 3 and 4 clinical trials.

Rheumatology (Oxford).

Moots RJ, Sebba A, Rigby W, Ostor A, Porter-Brown B, Donaldson F, Dimonaco S, Rubbert-Roth A, van Vollenhoven R, Genovese MC

doi: 10.1093/rheumatology/kew370.

Further Publications Dermatology

Tumor necrosis factor receptor-1 assciated periodic syndrome (TRAPS) related AA amyloidosis: a national case series and systematic review

Rheumatology (Oxford)

Delaleu J, Deshayes S, Rodrigues F, Savey L, Rivière E, Martin Silva N, Aouba A, Amselem S, Rabant M, Grateau G, Giurgea I, Georgin-Lavialle S

doi: 10.1093/rheumatology/keab252

Juvenile Idiopathic Arthritis

Treat-to-target using first-line recombinant interleukin-1 receptor antagonist monotherapy in new-onset systemic juvenile idiopathic arthritis: results from a five year follow-up study

Arthritis Rheumatol.

Ter Haar NM, van Dijkhuizen EHP, Swart JF, van Royen-Kerkhof A, El Idrissi A, Leek AP, de Jager W, de Groot MCH, Haitjema S, Holzinger D, Foell D, van Loosdregt J, Wulffraat NM, de Roock S, Vastert SJ

doi: 10.1002/art.40865.

Systemic Lupus Erythematosus

Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus

Lupus Sci Med.

Riggs JM, Hanna RN, Rajan B, Zerrouki K, Karnell JL, Sagar D, Vainshtein I, Farmer E, Rosenthal K, Morehouse C, de Los Reyes M, Schifferli K, Liang M, Sanjuan MA, Sims GP, Kolbeck R

doi: 10.1136/

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