Adverse Effects of Second-Generation Antipsychotics as Adjuncts to Antidepressants: Are the Risks Worth the Benefits?

Anxiety and DepressionBipolar Disorder

Safety and efficacy of adjunctive second-generation antidepressant therapy with a mood stabiliser or an atypical antipsychotic in acute bipolar depression: a systematic review and meta-analysis of randomised placebo-controlled trials

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Effects of first-generation antipsychotics versus second-generation antipsychotics on quality of life in schizophrenia: a double-blind, randomised study

Lancet Psychiatry.

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Clinical factors associated with augmentation treatment with second-generation antipsychotics and lithium in major depression - Results from a European multicenter study

Eur Neuropsychopharmacol.

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doi: 10.1016/j.euroneuro.

DementiaPsychosis and Schizophrenia

Second-generation antipsychotic drugs and short-term mortality: a systematic review and meta-analysis of placebo-controlled randomised controlled trials

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Anxiety and Depression

Efficacy and safety of levomilnacipran, vilazodone and vortioxetine compared with other second-generation antidepressants for major depressive disorder in adults: A systematic review and network meta-analysis

J Affect Disord.

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doi: 10.1016/j.jad.2017.11.056.

Anxiety and Depression

Treatment Response of Add-On Esketamine Nasal Spray in Resistant Major Depression in Relation to Add-On Second-Generation Antipsychotic Treatment

Int J Neuropsychopharmacol.

Dold M, Bartova L, Kasper S

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Bipolar Disorder

Maintenance therapy with second generation antipsychotics for bipolar disorder - A systematic review and meta-analysis

J Affect Disord.

Lindström L, Lindström E, Nilsson M, Höistad M

doi: 10.1016/j.jad.2017.02.012.

Bipolar Disorder

Conventional mood stabilizers and/or second-generation antipsychotic drugs in bipolar disorders: A population-based comparison of risk of treatment failure

J Affect Disord.

Tournier M, Neumann A, Pambrun E, Weill A, Chaffiol JP, Alla F, Bégaud B, Maura G, Verdoux H

doi: 10.1016/j.jad.2019.07.054.

Can melatonin prevent or improve metabolic side effects during antipsychotic treatments?

Neuropsychiatr Dis Treat.

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doi: 10.2147/NDT.S127564.

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