Tramadol/dexketoprofen (TRAM/DKP) compared with tramadol/paracetamol in moderate to severe acute pain: results of a randomised, double-blind, placebo and active-controlled, parallel group trial in the impacted third molar extraction pain model (DAVID study)

Acute Pain

Efficacy and safety of multiple doses of tapentadol oral solution in the treatment of moderate to severe acute pain in children aged 2 to <18 years - a randomized, double-blind, placebo-controlled trial

J Pain Res.

Beuter C, Volkers G, Radic T, Goldberg J, van den Anker J

doi: 10.2147/JPR.S207010.

Respiratory Tract Infection

Safety and efficacy of upadacitinib in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis (AD Up): results from a randomised, double-blind, placebo-controlled, phase 3 trial

Lancet

Reich K, Teixeira HD, de Bruin-Weller M, Bieber T, Soong W, Kabashima K, Werfel T, Zeng J, Huang X, Hu X, Hendrickson BA, Ladizinski B, Chu AD, Silverberg JI

doi: 10.1016/S0140-6736(21)00589-4

Respiratory Tract Infection

Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double-blind, randomised controlled phase 3 trials

Lancet

Guttman-Yassky E, Teixeira HD, Simpson EL, Papp KA, Pangan AL, Blauvelt A, Thaçi D, Chu CY, Hong HC, Kato N, Paller AS, Calimlim B, Gu Y, Hu X, Liu M, Yang Y, Liu J, Tenorio AR, Chu AD, Irvine AD

doi: 10.1016/S0140-6736(21)00588-2

Back Pain

Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes (the AIM study): double blind, randomised, placebo controlled, multicentre trial

BMJ.

Bråten LCH, Rolfsen MP, Espeland A, Wigemyr M, Aßmus J, Froholdt A, Haugen AJ, Marchand GH, Kristoffersen PM, Lutro O, Randen S, Wilhelmsen M, Winsvold BS, Kadar TI, Holmgard TE, Vigeland MD, Vetti N, Nygaard ØP, Lie BA, Hellum C, Anke A, Grotle M, Schistad EI, Skouen JS, Grøvle L, Brox JI, Zwart JA, Storheim K, AIM study group.

doi: 10.1136/bmj.l5654.

Acute PainPostoperative Pain

APOLLO-1: a randomized placebo and active-controlled phase III study investigating oliceridine (TRV130), a G protein-biased ligand at the µ-opioid receptor, for management of moderate-to-severe acute pain following bunionectomy

J Pain Res.

Viscusi ER, Skobieranda F, Soergel DG, Cook E, Burt DA, Singla N

doi: 10.2147/JPR.S171013.

Postoperative Pain

Efficacy and Safety of Intravenous Meloxicam in Patients With Moderate-to-Severe Pain Following Bunionectomy: A Randomized, Double-Blind, Placebo-controlled Trial

Clin J Pain.

Pollak RA, Gottlieb IJ, Hakakian F, Zimmerman JC, McCallum SW, Mack RJ, Keller R, Freyer A, Du W

doi: 10.1097/AJP.

Pain Relief

Tapentadol prolonged-release for moderate-to-severe chronic osteoarthritis knee pain: a double-blind, randomized, placebo- and oxycodone controlled release-controlled study

Curr Med Res Opin.

Serrie A, Lange B, Steup A

doi: 10.1080/

Postoperative Pain

Efficacy and safety of single-dose DFN-15 for treatment of acute postsurgical dental pain: a randomized, double-blind, placebo-controlled study

Pain

Singla N, Bertoch T, Shenoy S, Munjal S

doi: 10.1097/j.pain.0000000000002312

COMMENTED

Obstetric PainSpinal Anesthesia

Subarachnoid block and ultrasound-guided transversalis fascia plane block for caesarean section: A randomised placebo-controlled double-blind study

★ 3 Recommended and commented by Dr Roland Schreiber, Faculty Member

Eur J Anaesthesiol.

Aydin ME, Bedir Z, Yayik AM, Celik EC, Ates İ, Ahiskalioglu EO, Ahiskalioglu A

doi: 10.1097/EJA.0000000000001222.

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