Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells

Diabetes - GeneralType 1 DiabetesType 2 Diabetes

Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood

JAMA.

Dabelea D, Stafford JM, Mayer-Davis E, D'Agostino R Jr, Dolan L, Imperatore G, Linder B, Lawrence JM, Marcovina SM, Mottl AK, Black MH, Pop-Busui R, Saydah S, Hamman RF, Pihoker C; SEARCH for Diabetes in Youth Research Group

doi: 10.1001/jama.2017.0686.

COMMENTED

Diabetes - GeneralType 1 Diabetes

Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables

Diabetologia.

Wentworth JM, Bediaga NG, Giles LC, Ehlers M, Gitelman SE, Geyer S, Evans-Molina C, Harrison LC; Type 1 Diabetes TrialNet Study Group; Immune Tolerance Network Study Group

doi: 10.1007/s00125-018-4722-z.

COMMENTED

Diabetes - GeneralType 1 Diabetes

Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes

Diabetes Care.

Haller MJ, Schatz DA, Skyler JS, Krischer JP, Bundy BN, Miller JL, Atkinson MA, Becker DJ, Baidal D, DiMeglio LA, Gitelman SE, Goland R, Gottlieb PA, Herold KC, Marks JB, Moran A, Rodriguez H, Russell W, Wilson DM, Greenbaum CJ; Type 1 Diabetes TrialNet ATG-GCSF Study Group

doi: 10.2337/dc18-0494.

COMMENTED

Type 1 DiabetesType 2 Diabetes

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

doi: 10.1038/s41574-020-0355-7.

COMMENTED

Type 2 Diabetes

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

Diabetes Care.

Grubb AL, McDonald TJ, Rutters F, Donnelly LA, Hattersley AT, Oram RA, Palmer CNA, van der Heijden AA, Carr F, Elders PJM, Weedon MN, Slieker RC, 't Hart LM, Pearson ER, Shields BM, Jones AG

doi: 10.2337/dc18-0431.

COMMENTED

Type 1 Diabetes

Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis

Diabetologia.

Perdigoto AL, Preston-Hurlburt P, Clark P, Long SA, Linsley PS, Harris KM, Gitelman SE, Greenbaum CJ, Gottlieb PA, Hagopian W, Woodwyk A, Dziura J, Herold KC; Immune Tolerance Network

doi: 10.1007/s00125-018-4786-9.

Type 1 DiabetesDiabetic ComplicationsPediatric Diabetes

Diabetic ketoacidosis in children newly diagnosed with type 1 diabetes mellitus: role of demographic, clinical and biochemical features along with genetic and immunological markers as risk factors. A twenty-year experience in a tertiary Belgian centre

Pediatr Diabetes.

Vicinanza A, Messaaoui A, Tenoutasse S, Dorchy H

doi: 10.1111/pedi.12864.

RECOMMENDED

Type 1 Diabetes

Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes

doi: 10.2337/dc18-0861.

COMMENTED

Type 1 Diabetes

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis

★ 1 Recommended and commented by Prof. emer. Dr Ulrich Keller, Faculty Member

doi: 10.1007/s00125-020-05115-6.

Related content

Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood

Beta cell function in type 1 diabetes determined from clinical and fasting biochemical variables

Low-Dose Anti-Thymocyte Globulin (ATG) Preserves β-Cell Function and Improves HbA1c in New-Onset Type 1 Diabetes

Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

A Type 1 Diabetes Genetic Risk Score Can Identify Patients With GAD65 Autoantibody-Positive Type 2 Diabetes Who Rapidly Progress to Insulin Therapy

Treatment of type 1 diabetes with teplizumab: clinical and immunological follow-up after 7 years from diagnosis

Diabetic ketoacidosis in children newly diagnosed with type 1 diabetes mellitus: role of demographic, clinical and biochemical features along with genetic and immunological markers as risk factors. A twenty-year experience in a tertiary Belgian centre

Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes

Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis